KMID : 0624620230560050296
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BMB Reports 2023 Volume.56 No. 5 p.296 ~ p.301
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Alleviation of imiquimod-induced psoriasis-like symptoms in Ror¥á-deficient mouse skin
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Park Koog-Chan
Kim Ji-Won Lee A-Ram Yu Su-Jong Kim Yoon-Jun
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Abstract
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Retinoic acid receptor-related orphan receptor ¥á (ROR¥á) plays a vital role in various physiological processes, including metabolism, cancer, circadian rhythm, cerebellar development, and inflammation. Although ROR¥á is expressed in the skin, its role in skin physiology remains poorly elucidated. Herein, Ror¥á was expressed in the basal and suprabasal layers of the epidermis; however, keratinocyte-specific Ror¥á deletion did not impact normal epidermal formation. Under pathophysiological conditions, Ror¥á-deficient mice exhibited alleviated psoriasis-like symptoms, including relatively intact epidermal stratification, reduced keratinocyte hyperproliferation, and low-level expression of inflammatory cytokines in keratinocytes. Unexpectedly, the splenic population of Th17 cells was significantly lower in keratinocyte-specific ROR¥á deficient mice than in the control. Additionally, Ror¥á-deficiency reduced imiquimod-induced activation of nuclear factor-¥êB and STAT3 in keratinocytes. Therefore, we expect that ROR¥á inhibitors act on immune cells and keratinocytes to suppress the onset and progression of psoriasis.
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KEYWORD
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Imiquimod, Keratinocytes, Psoriasis, ROR¥á, STAT3
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